This appears to be a real clinical-trial calculator, but it can send cloud requests more readily than its safe-preview wording suggests and can fetch extra URLs supplied by the remote service.
Review before installing. Use --dry-run explicitly for previews, assume normal compute commands may send trial-design parameters, locale, and a stable hostname hash to the cloud endpoint, and avoid using confidential protocol details unless you are comfortable with extracted design parameters leaving the machine. The publisher should align the safe-preview docs with the actual CLI behavior and restrict response-followed URLs to trusted hosts.