# Disease Database Reference

## Overview

Comprehensive database covering 3000+ medical conditions for differential diagnosis.

## Body Systems Coverage

### 1. Cardiovascular (300+ conditions)
- Coronary artery disease
- Arrhythmias
- Heart failure
- Hypertension
- Valvular diseases

### 2. Respiratory (250+ conditions)
- Asthma
- COPD
- Pneumonia
- Pulmonary embolism
- Lung cancer

### 3. Gastrointestinal (400+ conditions)
- GERD
- Peptic ulcer disease
- Appendicitis
- Cholecystitis
- Inflammatory bowel disease

### 4. Neurological (350+ conditions)
- Stroke
- Seizure disorders
- Migraine
- Meningitis
- Multiple sclerosis

### 5. Musculoskeletal (300+ conditions)
- Fractures
- Arthritis
- Back pain
- Soft tissue injuries
- Osteoporosis

### 6. Dermatological (200+ conditions)
- Dermatitis
- Psoriasis
- Skin infections
- Melanoma
- Allergic reactions

### 7. Genitourinary (250+ conditions)
- UTIs
- Kidney stones
- Prostate disorders
- Gynecological conditions
- STIs

### 8. Endocrine (150+ conditions)
- Diabetes mellitus
- Thyroid disorders
- Adrenal disorders
- Pituitary disorders

### 9. Hematological (150+ conditions)
- Anemia
- Bleeding disorders
- Leukemia
- Lymphoma

### 10. Immunological (100+ conditions)
- Autoimmune diseases
- Immunodeficiency
- Allergies
- Transplant-related

### 11. Psychiatric (200+ conditions)
- Depression
- Anxiety disorders
- Bipolar disorder
- Schizophrenia
- Substance abuse

## Symptom-Disease Mapping

The system uses evidence-based associations between symptoms and potential diagnoses:

### Example Mappings

| Symptom | Top Differential Diagnoses |
|---------|---------------------------|
| Chest pain | ACS, PE, Aortic dissection, Pericarditis, GERD |
| Headache | Migraine, Tension headache, SAH, Meningitis |
| Abdominal pain | Appendicitis, Cholecystitis, Pancreatitis, IBS |
| Fever | Infection, Inflammatory conditions, Malignancy |

## Age-Specific Considerations

### Pediatric (0-18 years)
- Different vital sign ranges
- Unique disease presentations
- Developmental considerations

### Adult (18-65 years)
- Standard presentations
- Occupational exposures
- Lifestyle factors

### Geriatric (>65 years)
- Atypical presentations
- Polypharmacy effects
- Functional decline

## Gender-Specific Considerations

- Pregnancy-related conditions
- Gynecological/urological differences
- Hormonal influences

## Data Sources

- ICD-10/ICD-11 classifications
- Medical literature
- Clinical guidelines
- Epidemiological studies